대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.168.3-169
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- 2003
Retroviral Delivery of TIMP-2 Inhibits H-ras-induced Migration and Invasion in MCF10A Human Breast Epithelial Cells
- Ahn, Seong-Min (College of Pharmacy, Dongduk Women's University) ;
- Jeong, Seo-Jin (Inje University) ;
- Kim, Yeon-Soon (Korea Food and Drug Administration) ;
- Sohn, Yeo-Won (Korea Food and Drug Administration) ;
- Moon, Aree (Korea Food and Drug Administration)
- 발행 : 2003.10.01
초록
The matrix metalloproteases (MMPs) play important roles in invasion, metastasis and angiogenesis in various cell types. Tissue inhibitor of metalloprotease (TIMP)-2, an endogenopus inhibitor of MMP-2, has been shown to inhibit invasion and metastasis. We have previously shown that MMP-2 is responsible for the H-ras-induced invasive and migrative phenotypes in MCF10A human breast epithelial cells. Here, we investigated the effect of TlMP-2 overexpression on invasion and migration in H-ras MCF10A cells. (omitted)
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