Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Monitoring the Expression Profiles of Doxorubicin-Resistant Acute Myelocytic Leukemia Cells by DNA Microarray Analysis

  • Song, Ju-Han (College of Pharmacy, Chonnam National University) ;
  • Kim, Tae-Sung (College of Pharmacy, Chonnam National University)
  • Published : 2003.10.01
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Abstract

Anticancer drug resistance occasionally occurs in malignant hematologic diseases such as acute myelocytic leukemia (AML) treated with chemotherapy and is a major problem to complete remission. Malignant cells primarily induce intrinsic resistance to treatment of anticancer drug, but gradually obtain acquired resistance to cytotoxic activities of chemotherapy. In this study, we monitored the expression profiles of doxorubicin resistance-related genes in AML-2/DX100, a doxorubicin-resistant human acute myelocytic leukemia cell line. (omitted)

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