대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
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Transforming Growth Factor-$\beta$ (TGF)-$\beta$, Induces Invasion and Migration of MCF10A Human Breast Epithelial Cells

  • Kim, Eun-Sook (College of Pharmacy, Dongduk Women's University) ;
  • Kim, Mi-Sung (College of Pharmacy, Dongduk Women's University) ;
  • Moon, Aree (College of Pharmacy, Dongduk Women's University)
  • 발행 : 2003.10.01
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초록

Transforming growth factor (TGF)-$\beta$, a hormonally active polypeptide found in normal and transformed tissue, is a potent regulator of cell growth and differentiation. In this study, we examined the effect of TGF-$\beta$ on invasion and motility of MCF10A human breast epithelial cells. TGF-$\beta$-induced migration and invasive phenotype of the parental MCF10A cells in a dose-dependent manner. Activity of MMP-2 promoter was increased by TGF-b, suggesting that the TGF-$\beta$-induced invasive phenotype may possibly be mediated by MMP-2 rather than MMP-9. (omitted)

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