Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.162.2-162.2
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- 2003
Role of Spc105p in the maintenance of genome stability
- Sung, Hye-Ran (College of Pharmacy, Chungbuk National University) ;
- Han, Kyung-Cheol (College of Pharmacy, Chungbuk National University) ;
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Hong, Jin-Tae
(College of Pharmacy, Chungbuk National University)
;
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Lee, Chong-Kil
(College of Pharmacy, Chungbuk National University)
;
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Song, Suk-Gil
(College of Pharmacy, Chungbuk National University)
- Published : 2003.10.01
Abstract
Microtubule-organizing center (MOTC) plays pivotal roles in cell division process. Integrity of the spindle pole body (SPB) in Saccharomyces cerevisiae is required for migration and separation of sister chromatids in mitotic phase. Role of an essential SPB component, Spcl05, is poorly understood. Here we show that throughout all stage of cell division cycle, GFP-tagged Spcl05p localizes at SPB and its protein stability is fluctuated with mitosis-specific modifications. To gain new insights into the function of Spc105, we generated and characterized novel temperature sensitive spc105 mutants. (omitted)
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