Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Development of efficient detection methods of CDK2 (or 4) activities for mass screening

  • Jeon, Yong-Jin (ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd.) ;
  • Yeon, Seung-Woo (ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd.) ;
  • Kim, Tae-Yong (ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd.)
  • Published : 2003.10.01
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Abstract

Mammalian cell cycles are tightly regulated by cyclins, cyclin dependent kinase (CDK), Retinoblatoma (Rb) protein, and cellular CDK inhibitors (CDKI). Cyelin dependent kinases (CDK) are key enzymes regulating eukaryotic cell cycle. And also it is recognized that the abnormal increase of CDK activities is one of the common events in human cancer and CDK inhibitors have therapeutic values in cancer treatment. Until now it is known that over 10 different CKDs participate in cell cycle regulation. (omitted)

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