Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Characterization of Acharan Sulfate Binding Proteins in Murine Lewis Lung Carcinoma Cell

  • Joo, Eun-Ji (Natioral Product Research Institute, Seoul National University) ;
  • Hahn, Bum-Soo (National Institute of Agricultural Biotechnology) ;
  • Kim, Yeong-Shik (National Institute of Agricultural Biotechnology)
  • Published : 2003.10.01
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Abstract

We have focused on various biological activities of acharan sulfate (AS) isolated from the giant African snail Achatina fulica. In a previous study, AS showed antiangiogenic and immunomodulating activity. We also investigated antitumor activity of AS. In vitro AS had no cytotoxicity within 0 to 200 ug/ml in tumor cells such as Lewis lung carcinoma(LLC) , KM1214 (human colon cancer cell) and Caki-1 (human kidney cancer cell) by both MTT and SRB assay. In vivo AS was used to treat C57BL/6 mice bearing LLC by subscutaneous injection. (omitted)

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