대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.147.1-147.1
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- 2003
Anti-inflammatory and Antinociceptive Effects of Methanol Extract from the Fomes fomentarius
- Park, Young-Mi (College of Pharmacy, Kyung Hee University) ;
- Shin, Kyoung-Min (Sangji University) ;
- Kim, In-Tae (Kyungsung Universiyt) ;
- Park, Hee-Juhn (Kyungsung Universiyt) ;
- Choi, Jong-Won (Kyungsung Universiyt) ;
- Lee, Kyoung-Tae (Kyungsung Universiyt)
- 발행 : 2003.10.01
초록
As an attempt to search for bioactive natural products exerting antiinflammatory activity, we have evaluated the anti-inflammatory and antinociceptive activities of the methanol extract from the Fomes fomentarius (MEFF). MEFF (50, 100 mg/kg/day, p.o.) significantly reduced an acute paw edema induced by carrageenan in rats. When analgesic activity was measured by acetic acid-induced writhing test and hot plate test, MEFF showed a dose-dependent inhibition in animal models. In addition, MEFF potently inhibited the LPS-induced production of NO,
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