Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.146.2-147
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- 2003
Inhibitory effect of benzoxathiol LYR-71 compound on inflammatory enzymes and cytokines
- Kim, Min-Hee (College of Pharmacy, Chungbuk National University) ;
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Lee, Yong-Rok
(School of Chemical Engineering & Technology, Yeungnam University)
;
- Min, Kyung-Rak (School of Chemical Engineering & Technology, Yeungnam University) ;
- Kim, Young-Soo (School of Chemical Engineering & Technology, Yeungnam University)
- Published : 2003.10.01
Abstract
The benzoxathiol LYR-71 compound was discovered as an inhibitor of NF-kB transcriptional activity with an IC50 value of 5.4 uM. Furthermore, benzoxathiol LYR-71 compound inhibited the NF-kB binding activity to DNA in a dose-dependent manner, which was identified by EMSA with oligonucleotide corresponding to NF-kB consensus sequence. It is well known that NF-kB is an important transcription factor to regulate the expression of inflammatory enzymes (iNOS and COX-2) and cytokines (TNF, IL-1 and IL-6). (omitted)
Keywords