Enhanced apoptosis of IFN-$\gamma$ treated macrophage in a depleted nutritional state

Apoptosis has been implicated as an important mediator in immunosuppression observed in a depleted nutritional state. The recent report has indicated that IFN-$\gamma$ treated bone marrow macrophages were protected from apoptosis induced by several stimuli in complete medium condition. However, our previous study demonstrated that IFN-$\gamma$ treated peritoneal macrophages were enhanced the apoposis in a depleted nutritional state. Therefor, we investigated the apoptotic regulatory mechanism of IFN-$\gamma$ in malnutrition-induced macrophage. (omitted)