Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of cyclosporin A and tacrolimus on the cross-presentation capability of dendritic cells

  • Lee, Young-Ran (College of Pharmacy, Chungbuk National University) ;
  • Park, Eun-Ju (College of Pharmacy, Chungbuk National University) ;
  • Im, Sun-A (College of Pharmacy, Chungbuk National University) ;
  • Song, Suk-Gil (College of Pharmacy, Chungbuk National University) ;
  • Lee, Chong-Ki (College of Pharmacy, Chungbuk National University)
  • Published : 2003.10.01
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Abstract

Previously, we showed that cyclosporin A and tacrolimus, but not rapamycin, inhibit MHC class I-restricted presentation of exogenous antigen in dendritic cells (DCs). We further characterized the effects of cyclosporin A and tacrolimus on the uptake, processing and cross-presentation of a model antigen, ovalbumin (OVA), in DCs. Treatment of DCs with cyclosporin A or tacrolimus did not inhibit phagocytic activity of DCs. Instead, treatment of DCs with cyclosporin A or tacrolimus inhibited the expression of $H-2K^b$/ molecules complexed with the OVA peptied, SIINFEKL, specifically. (omitted)

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