Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Phospholipases Dl and D2 Regulate Different Phases of Exocytosis in Mast Cells

  • Lee, Jun-Ho (Department of Immunology, College of Medicine, Konkuk University) ;
  • Chang, Sung-Ho (Department of Pharmacy, Duksung Women's University) ;
  • Kim, Young-Mi (Department of Pharmacy, Duksung Women's University) ;
  • Her, Her Erk (Department of Pharmacy, Duksung Women's University) ;
  • Choi, Wahn-Soo (Department of Pharmacy, Duksung Women's University)
  • Published : 2003.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The rat mast cell line RBL-2H3 contains both phospholipase D (PLD)1 and PLD2. Previous studies with this cell line indicated that expressed PLD1 and PLD2 are both strongly activated by stimulants of secretion. We now show by use of PLDs tagged with enhanced green fluorescent protein that PLD1, which is largely associated with secretory granules, redistributes to the plasma membrane in stimulated cells by processes reminiscent of exocytosis and fusion of granules with the plasma membrane. (omitted)

Keywords