Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.130.2-130.2
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- 2003
Immunodulatory activity of betulinic acid from Lycopus lucidus in murine macrophage RAW 264.7 cells
- Yun, Yun-Ha (Department of Pharmacy, Sahmyook University) ;
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Song, Young-Chun
(Department of Pharmacy, Sahmyook University) ;
- Son, Han-Shik (Department of Pharmacy, Sahmyook University) ;
- Yim, Dong-Sool (Department of Pharmacy, Sahmyook University) ;
- Lee, Soo-Kyeon (Department of Pharmacy, Sahmyook University) ;
- Kim, Kyung-Jae (Department of Pharmacy, Sahmyook University)
- Published : 2003.10.01
Abstract
Betulinic acid (BA), a pentacyclic triterpene isolated from Lycopus lucidus, has been reported to be a selective inducer of apoptosis in various human tumor cells. It also exhibits anti-inflammatory and immunomodulatory properties. Due to its high level of these activities and lack of toxicity, BA is an attractive and promising compound as a new drug and recently undergoing preclinical development as an immunomodulators. How BA mediates these matters is not known yet. (omitted)
Keywords