대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.127.2-128
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- 2003
Effect of Ascorbic Acid on the Activity and Gene Expression of Cytochrome P450 in Sepsis
- Kim, Joo-Young (College of Pharmacy, Sungkyunkwan University) ;
- Park, Sang-Woo (College of Pharmacy, Sungkyunkwan University) ;
- Lee, Sun-Mee (College of Pharmacy, Sungkyunkwan University)
- 발행 : 2003.10.01
초록
Sepsis remains common surgical problems with high morbidity and mortality despite improvement in the management for septic patient. Although hepatocellular dysfunction occurs during sepsis, the mechanism responsible for this remains unclear. In sepsis, a state of severe oxidative stress is encountered, with host endogenous antioxidant defenses overcome. Therefore, the aim of this study was to determine whether specific abnormality exists in cytochrome P450 (CYP)-mediated metabolizing function associated with polymicrobial sepsis and whether role of ascorbic acid (AA) in the alterations during sepsis. (omitted)
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