Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.123.2-123.2
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- 2003
Hypothetical Mechanisms of G protein-coupled neurodegeneration in glutamate excitotoxicity in human SH-SY5Y neuroblastoma cells
- Nikolova, Nikolova Sevdalina (Departmemt of Biotechnology Graduate School, Yeungnam University) ;
- Jin, Da-Qing (College of Pharmacy, Yeungnam University) ;
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Kim, Jung-Ae
(College of Pharmacy, Yeungnam University)
- Published : 2003.10.01
Abstract
The cellular mechanisms by which excess exposure to the excitatory neurotransmitter glutamate can produce neuronal injury are unknown. In this study, we found that glutamate induced cell death at IC (50) of 100 microM on the cultured human SH-SY5Y neuroblastoma cells. It has been hypothesized that glutamate excitotoxicity is related with the elevation of calcium (Ca) levels. To determine the dependence of glutamate neurotoxicity on Ca environment, extracellular (EDTA) and intracellular (BAPTA/AM) chelator were used. (omitted)
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