Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.121.2-121.2
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- 2003
Up-regulation of inducible nitric oxide synthase expression and inflammatory cytokines by collagen and gelatin in murine macrophages
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Kim, Ji-Young
(Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University)
;
- Lee, Kyung-Jin (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Oh, Duk-Hee (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Jung, Kyung-Sik (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Shin, Dong-Weon (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Cho, Young-Rhan (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Jeong, Hye-Gwang (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University)
- Published : 2003.10.01
Abstract
Synthetic polymers, biological polymer such as collagen and gelatin are employed extensively as backbones in the construction of hydrogels or cell/tissue scaffoldings for various biomedical applications. In the present study, we investigated the effect of collagen and gelatin on the inducible nitric oxide synthase (iNOS) gene expression in the mouse macrophage cell line RAW 264.7. The production of nitric oxide and expression level of iNOS mRNA were induced by both of collagen and gelatin in dose-dependent manner. (omitted)
Keywords