대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Induction of apoptosis by dihydro-N-caffeoyltyramine on human leukemia cells

  • Choi, Chul-Yung (Division of Food Science, Jinju International University) ;
  • Kim, Ji-Young (Department of Pharmacy and Research Center for Proteineous Materials, Chosun University) ;
  • Lee, Kyung-Jin (Department of Pharmacy and Research Center for Proteineous Materials, Chosun University) ;
  • Oh, Duk-Hee (Department of Pharmacy and Research Center for Proteineous Materials, Chosun University) ;
  • Han, Song-Hee (Department of Pharmacy and Research Center for Proteineous Materials, Chosun University) ;
  • Woo, Eun-Rhan (Department of Pharmacy and Research Center for Proteineous Materials, Chosun University) ;
  • Jeong, Hye-Gwang (Department of Pharmacy and Research Center for Proteineous Materials, Chosun University)
  • 발행 : 2003.10.01
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초록

Lycii Radicis Cortex, the root bark of Lycium chinense Miller (Solanaceae) is used in oriental medicine as a tonic and is reported to exhibit hypotensive, hypoglycemic, and antipyretic activity. Recently, we have isolated dihydro-N-caffeoyltyramine, a phenolic amide, from the Lycii Radicis Cortex. Treatment with dihydro-N-caffeoyltyramine significantly inhibited the proliferation of human leukemia cell lines HL-60 in a dose-dependent manner. We found also that the growth inhibition of HL-60 by dihydro-N-caffeoyltyramine is associated with induction of apoptosis of cells. (omitted)

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