Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Aspirin Inhibits Dimethylnitrosamine-Induced Liver Damage in Rats

  • Lee, Dong-Soo (College of Pharmacy, Pusan National University) ;
  • Lee, Hye-Eun (College of Mediciney, Pusan National University) ;
  • Shin, Ji-Young (College of Mediciney, Pusan National University) ;
  • Lee, Hee-Woo (College of Mediciney, Pusan National University) ;
  • Chung, Hae-Young (College of Mediciney, Pusan National University) ;
  • Yoon, Sik (College of Mediciney, Pusan National University) ;
  • Moon, Jeon-Ok (College of Mediciney, Pusan National University)
  • Published : 2003.10.01
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Abstract

Aspirin and aspirin-like nonsteroidal antiinflammatory drug have been the mainstay of therapy for rheumatoid arthritis. In this study, we investigated the hepatoprotective effect of aspirin on the dimethylnitrosamine (DMN)-induced liver damage in rats. Oral administration of aspirin (7.5, 15mg/kg daily for 4 weeks) into the DMN-treated rats remarkably prevented the elevation of serum alanine transaminase, aspartate transaminase and alkaline phosphatase, and bilirubin levels. Aspirin also increased serum protein level and reduced the hepatic level of malondialdehyde in DMN-treated rats. (omitted)

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