Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of zinc and resveratrol on cadmium-induced apoptosis and cell arrest in MCF-7 and MDA-MB-231 cells

  • Lee, Su-Jung (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Ho, Shin-Jae (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Kim, Tae-Sung (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Moon, Hyun-Ju (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Kang, Il-Hyun (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Kim, In-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Oh, Ji-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Lee, Young-Ju (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Kim, An-Keun (College of Pharmacy, Sookmyung Women's University) ;
  • Han, Soon-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA)
  • Published : 2003.10.01
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Abstract

Cadmium, a human carcinogen, can induce apoptosis in various cell lines. Despite extensive research, the mechanisms of cadmium-induced apoptosis are poorly understood, and its toxicity and estrogenic potential in human are not clear. This study was performed to investigate the apoptotic activities of cadmium on two human breast cancer cell lines: MCF-7 cells, an estrogen receptor (ER) positive cell line, and MDA-MB-231 cells, an ER negative cell line. Both cells were treated with $CdCl_2$ 100$\mu$M for 12hrs, and the spoptosis was determined by DNA fragmentation, DAPI staining, and expression of caspase-9. (omitted)

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