Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.112.2-112.2
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- 2003
Effect of B-ring -OH numbers of 5,7-dihydroxyflavone on the activity of CYP 1 enzymes
- Lee, Sang-Bum (School of Life Sciences and Biotechnology and KRIBB) ;
- Kim, Hyun-Jung (School of Life Sciences and Biotechnology and KRIBB) ;
- Kim, Hwan-Mook (School of Life Sciences and Biotechnology and KRIBB) ;
- Park, Young-In (School of Life Sciences and Biotechnology and KRIBB) ;
- Dong, Mi-Sook (School of Life Sciences and Biotechnology and KRIBB)
- Published : 2003.10.01
Abstract
CYP1 enzymes, CYP1A1, CYP1A2 and CYP1B1, are known to bioactivate procarcinogens particularly polyaromatic compounds. Flavonoids are a class of natural compounds that are present in edible plants. Structurally, these compounds are polyphenols with two aromatic rings (A, B) and a heterocycyclic ring (C). We observed the differential inhibition of 5,7-dihydroxyflavones which are different in numbers of B-ring-OH, to the activity of ethoxyresorufin O-deethylase (EROD) in human hepatic microsomes with the IC50 values, ie, 0.57 mM, 1.28 mM, and 3.62 mM, chrysin, apigenin, and Luteolin, respectively. (omitted)
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