The altered $Na^+,\;K^+$-pump activity following the fumonisin exposure to LLC-PKl cells

Choi, Heon-Kyo;Yoo, Jae-Myung;Tudev, Munkhtsetseg;Lee, Yong-Moon;Yun, Yeo-Pyo;Yoo, Hwan-Soo;

Proceedings of the PSK Conference (대한약학회:학술대회논문집)

2003.10b
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Pages.110.1-110.1
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2003

The Pharmaceutical Society of Korea (대한약학회)

The altered $Na^+,\;K^+$-pump activity following the fumonisin exposure to LLC-PKl cells

Choi, Heon-Kyo (Chungbuk National University, College of Pharmacy) ;
Yoo, Jae-Myung (Chungbuk National University, College of Pharmac) ;
Tudev, Munkhtsetseg (Chungbuk National University, College of Pharmac) ;
Lee, Yong-Moon (Chungbuk National University, College of Pharmac) ;
Yun, Yeo-Pyo (Chungbuk National University, College of Pharmac) ;
Yoo, Hwan-Soo (Chungbuk National University, College of Pharmacy)

Published : 2003.10.01

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Abstract

Fumonisins are specific inhibitors of ceramide synthase in sphingolipid metabolism. Sphingolipids are biologically active lipid mediators in cellular physiology and involved in cell signaling, growth, transformation, angiogenesis and differentiation. The objective of this study was to determine the effect of fumonisin B1 on $Na^+, \;K^+$-pump activity when fumonisin B1 was exposed to LLC-PK1 cells. Fumonisin B1 elevated free sphingoid bases and their 1-phosphates, while total complex sphingolipids were depleted at 20$\mu$M fumonisin B1 during the 3 day exposure. (omitted)

Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The altered $Na^+,\;K^+$-pump activity following the fumonisin exposure to LLC-PKl cells

Abstract

Keywords