Identification of Proteineous Biomarkers for Cadmium- and Ceramide- Induced Toxicity in Human Brain Cells through Display Proteomic Analysis

  • Oh, Mi-Jung (Department of Environmental & Health Chemistry, Collage of Pharmacy, Chung-Ang University) ;
  • Chae, Kyu-Young (Department of Environmental & Health Chemistry, Collage of Pharmacy, Chung-Ang University) ;
  • Park, Mi-Ja (Department of Environmental & Health Chemistry, Collage of Pharmacy, Chung-Ang University) ;
  • Cho, Dong-Hawn (Department of Environmental & Health Chemistry, Collage of Pharmacy, Chung-Ang University) ;
  • Kim, Dae-Kyong (Department of Environmental & Health Chemistry, Collage of Pharmacy, Chung-Ang University)
  • Published : 2003.10.01

Abstract

Cadmium is an environmental pollutant and exhibits nephrotoxicity, hepatotoxicity and immunotoxicity. Recently, cadmium was found to induce DNA fragmentation, a biochemical hallmark of apoptosis, in cultured renal cells, hepatocytes and neuroblastoma cell. Therefore, the various toxicities of cadmium are thought to be caused by the induction of apoptosis. Lipids-derived pro-apoptotic ceramide has emerged as an important intracellular signaling molecule that mediates diverse cellular effects, of which programmed cell death, or apoptosis, has attracted significant interest. (omitted)

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