Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.103.2-103.2
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- 2003
Heat Shock Protein 60 Is a $Mg^{2+}$ -dependent, Membrane-associated and Neutral Sphingomyelinase That Mediates TNF-alpha Signaling
- Jung, Sang-Mi (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University) ;
- Jung, Sung-Yun (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University) ;
- Chang, Dong-Hoon (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University) ;
- Jeong, Hyun-Chul (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University) ;
- Chin, Mi-Reyoung (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University) ;
- Jeong, Eui-Man (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University) ;
- Jo, Dong-Hwan (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University) ;
- Jeon, Hyung-Jun (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University) ;
- Jung, Kwnag-Mook (Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University)
- Published : 2003.10.01
Abstract
The hydrolysis of sphingomyelin (SM), known as the SM pathway, is induced by the activation of sphingomyelinase (SMase) to generate the second messenger ceramide, which plays a key role in cellular responses such as apoptosis, differentiation, senescence, and inflammation. Here, we identified a 60 kDa membrane-associated, neutral and Mg
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