Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.102.2-103
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- 2003
Comparative Study of the Inhibitory Effect of Luteolin and Luteolin-7-Glucoside on Rat Aortic Vascular Smooth Muscle Cell Proliferation
- Kim, Jin-Ho (College of Pharmacy, Chungbuk National University) ;
- Kim, Soo-Yeon (School of Agricultural Biotechnology, Seoul National University) ;
- Lim, Yong (School of Agricultural Biotechnology, Seoul National University) ;
- Pyo, Hyeong-Bae (School of Agricultural Biotechnology, Seoul National University) ;
- Park, Byeoung-Soo (School of Agricultural Biotechnology, Seoul National University) ;
- Yoo, Hwan-Soo (School of Agricultural Biotechnology, Seoul National University) ;
- Yun, Yeo-Pyo (School of Agricultural Biotechnology, Seoul National University)
- Published : 2003.10.01
Abstract
It has been previously reported that luteolin and luteolin-7-glucoside displayed the potent anti-oxidant and anti-inflammatory effects, which have also been successful in reducing vascular smooth muscle cells(VSMCs) proliferation. In this study, a possible anti-proliferative effect and its mechanism on rat aortic VSMCs by luteolin and luteolin-7-glucoside were investigated. Luteolin significantly inhibited the platelet-derived growth factor(PDGF)-BB-induced proliferation of rat aortic VSMCs. While luteolin-7-glucoside weakly inhibited the proliferation. (omitted)
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