대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
- /
- Pages.98.2-99
- /
- 2003
A long duration of anticoagulant activity of acharan sulfate in vivo
- Li, Da-Wei (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
- Lee, In-Sun (Graduate School of Pharmaceutical Science, Chiba University) ;
- Toshihiko Toida (Graduate School of Pharmaceutical Science, Chiba University) ;
- Kim, Yeong-Shik (Graduate School of Pharmaceutical Science, Chiba University)
- 발행 : 2003.10.01
초록
Introduction: We previously reported that a new glycosaminoglycan, acharan sulfate (AS) from the African giant snail Achatina fulica showed anticoagulation activity in vitro, but it was much less than that of heparin. In the present study, the anticoagulant activity of AS was investigated in vivo. Methods: AS and heparin were administered to rats in various concentrations and anticoagulant activities were measured. Both were also compared in thrombin-induced Results: Intravenous administration of acharan sulfate prolonged the coltting time (APTT) in mice and rats in a dose-dependent manner. (omitted)
키워드