Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.95.2-96
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- 2003
Sphingosine-1-Phosphate-Induced ERK Activation Protects Human Melanocytes from UVB-Induced Apoptosis
- Kim, Dong-Seok (Research Division for Human Life Sciences, Seoul National University) ;
- Kim, Sook-Young (Department of Dermatology, Seoul National University) ;
- Lee, Jai-Eun (College of Medicine, Department of Pharmacolog) ;
- Kwon, Sun-Bang (College of Pharmacy, Chung-Ang University) ;
- Sohn, Uy-Dong (College of Pharmacy, Chung-Ang University) ;
- Park, Kyoung-Chan (College of Pharmacy, Chung-Ang University)
- Published : 2003.10.01
Abstract
Ultraviolet B (UVB) is known to induce apoptosis in human melanocytes. Here we show the cytoprotective effect of sphingosine-1-phosphate (S1P) against UVB-induced apoptosis. We also show that UVB-induced apoptosis of melanocytes is mediated by caspase-3 activation and poly(ADP-ribose) polymerase (PARP) cleavage, and that S1P prevents apoptosis by inhibiting this apoptotic pathway. We further investigated three major subfamilies of mitogen-activated protein (MAP) kinases and the Akt pathway after UVB irradiation. (omitted)
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