Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.94.1-94.1
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- 2003
Protective effect of metabolized Chungpesagan-tang on Hypoxia/Reperfusion induced-PC12 cell damage
- Lee, Eun-Su (Dept Pharmacology, School of Dentistry, Chonbuk National Univ.) ;
- Park, Jung-Ran (Graduate School of East West Medical Sciences, Kyung Hee Univ) ;
- Sohn, Nak-Won (Graduate School of East West Medical Sciences, Kyung Hee Univ) ;
- Soh, Yun-Jo (Graduate School of East West Medical Sciences, Kyung Hee Univ.)
- Published : 2003.10.01
Abstract
This research was performed to investigate the protective effect of Chungpesagan-tang (CPS) against ischemic damage in PC12 cells. To elucidate the mechanism of the protective effect of CPS on ischemic insult, cell viability and changes in activities of Superoxide dismutase, Glutathione Peroxidase, Catalase, Caspase 3 and the production of Malondialdehyde were observed after treating PC12 cells with CPS which was metabolized by rat liver homogenate. Pretreatment of CPS with liver homogenate increased its protective effect against ischemic insult by reducing the harmful effect of CPS itself. (omitted)
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