Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Oxyresveratrol Derivative Compound DMPB Act as Potent Dipigment agent in Brown Guinea Pig Skin

  • Choi, Sang-Yoon (Gradurate School of East-West Medical Science, Kyunghee University) ;
  • Kim, Sang-Hee (Natural Products Reserch Institute, Seoul Natioal University) ;
  • Hwang, Jae-Sung (Skin Reserch Institute, Amore-Pacific Cor) ;
  • Kim, Ho-Cheol (Skin Reserch Institute, Amore-Pacific Cor) ;
  • Kim, Sun-Yeou (Skin Reserch Institute, Amore-Pacific Corp)
  • Published : 2003.10.01
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Abstract

This study with the object of reported to depigment agent, oxyresveratrol derivative, compound DMPB. Compound DMPB with a two methoxy groups and modified connection chain. It was synthesized in accordance with a simple combination process. Compound DMPB exhibits depigmentaion ability on ultraviolet B-induced hyperpigmention of the brown guinea pig skin. In addition, this Compound exhibited 30% inhibitory effect of melanin generation without cell toxicity as a result of the treatment with 100 ppm in melan-a cells. (omitted)

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