대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.91.2-91.2
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- 2003
Induction of cell cycle arrest and apoptosis by an indirubin analog, a CDK inhibitor, in human lung cancer cells
- Lee, Jong-Won (College of Pharmacy Ewha Womans University) ;
- Moon, Myung-Ju (Kwangju Institute of Science & Technolog) ;
- Kim, Yong-Chul (Kwangju Institute of Science & Technolog) ;
- Lee, Sang-Kook (Kwangju Institute of Science & Technology)
- 발행 : 2003.10.01
초록
Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation. Inhibition of CDK is a promising target in development of anti-cancer agents. An indirubin analog (AGM01l), a CDK inhibitor, is a synthetic compound that inhibits human cancer cell growth in vitro. AGM01l showed a potent cytotoxicity in cultured human cancer cell lines (IC
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