Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.89.2-89.2
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- 2003
Regulation of c-fos promoter through interaction between dopamine D3 receptor and RGL, ral GDP dissociation stimulator-like
- Park, Ju-Ran (College of Pharmacy, Chonnam National University) ;
- Kim, So-Young (College of Pharmacy, Chonnam National University) ;
- Kim, Kyeong-Man (College of Pharmacy, Chonnam National University)
- Published : 2003.10.01
Abstract
Ral GDP dissociation stimulator (Ral GDS) has been found to be an effector protein of Ras, and Ral, a member of small GTP-binding protein (G protein) superfamily, has been suggested to act downstream of Ras. Ral GDP dissociation stimulator-like (RGL) shares 50% amino acid identity with Ral GDP dissociation stimulator, and assumed to possess similar functional role. Using yeast two-hybrid screening, we found that dopamine D3 receptor interacts with RGL. Since RGL is known to regulate the expression of c-fos promoter, effects of D3R on gene expression of c-fos promoter was studied. (omitted)
Keywords