Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Antifibrotic and Antioxidative Effect of Solanum lycopersicum in Liver fibrosis(Cirrhosis) induced Rats

  • Kim, Ki-Young (Dept. of Pathology, Medical School) ;
  • Oh, Se-Mi (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Jin-Sook (Dept. of Herbal Pharmaceutical Develop, Institut of Oriental Medicine, Seoul, Kore) ;
  • Somasundaram, Rajan (Gastroenterologie/ Infektiologie/Rheumatologie/Liver Research, Universitaetsklinikum der Charite Universitaetsmedizin Berlin, German) ;
  • Ruehl, Martin (Gastroenterologie/ Infektiologie/Rheumatologie/Liver Research, Universitaetsklinikum der Charite Universitaetsmedizin Berlin, German) ;
  • Matthes, Burkhard (Forschungsinstitut Havelhoehe, Berlin, Germany)
  • Published : 2003.10.01
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Abstract

Introduction: Liver fibrosis is defined unbalance of collagen metabolism, especially a stimulation of collagen synthesis and inhibition of collagen degradation, and antifibrotic effect is delaying or inhibition of new collagen synthesis and deposition in liver tissue. In this study, we investigated the antifibrotic and antioxidative effect of Solanum lycopersicum (SL) in liver fibrosis induced rats. Methods: : Rats were randomly divided in three groups (normal, CCl$_4$ and CCl$_4$-SL group) and were received 0.6 ml mixture of CCl$_4$ and olived oil (1:1 v/v) 3 times/week for 4 weeks except of the normal group. (omitted)

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