Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.84.1-84.1
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- 2003
Changes of M1 muscarinic receptor mRNA and $[^3H]$ pirenzepine receptor binding in the brain of sensitized mice by methamphetamine administration
- Kim, Kyung-In (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
- Yoo, Ji-Hoon (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
- Cho, Jae-Han (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
- Im, Ki-Dong (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
- Lee, Seok-Yong (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
- Lee, Sun-Bok (Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
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Jang, Choon-Gon
(Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University)
- Published : 2003.10.01
Abstract
Methamphetamine is a powerful stimulant that appears to produce locomotor activity and behavioral sensitization. Previous study has indicated that dopaminergic receptors are implicated in the behavioral responses of methamphetamine. Recently, it has been reported that other receptors, especially, M1 muscarinic acetylcholine receptor (M1R) plays an important role in the regulation of behavioral responses, and this receptor is abundantly expressed in brain regions, including the cerebral cortex, striatum, and the hippocampus of the animal. (omitted)
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