Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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(-) 3,5-Dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells: through tyrosine kinase cascade signaling

  • Hur, Jin-Young (Kyunghee University, School of East West medical Science Herbal pharmacology, National Institute of Agricultural Science & Technology) ;
  • Lee, Pyeong-Jae (Department of Sericulture and Entomology, Kyunghee University) ;
  • Kim, Ho-Cheol (School of East West Medical science, Herbal pharmacology, Kyunghee University) ;
  • Kang, In-Sug (school of medicine, Department of biochemistry, SungKyunKwan University) ;
  • Lee, Kang-Lo (College of pharmacy, Kyunghee universit) ;
  • Kim, Sun-Yeou (School of East-West medical science, Herbal pharmacology)
  • Published : 2003.10.01
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Abstract

Aster scaber T. (Asteraceae) has been used in traditional Korean and Chinese medicine to treat bruises, snakebites, headaches and dizziness. (-) 3,5-Dicaffeoyl-muco-quinic acid (DQ) isolated from Aster scaber induced neurite outgrowth in PC12 cells. It has been reported that the activation of the extracellular signal regulated kinase1/2 (Erk 1/2) and phosphoinositide 3 (P13) kinase plays a crucial role in the NGF-induced differentiation of PC12 cells. This study showed that the effect of DQ on neurite outgrowth is mediated via the Erk 1/2 and PI3 kinase-dependent pathways like NGF. (omitted)

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