Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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The protective mechanism of melatonin on carrageenan-induced paw edema generation in rats

  • Min, Young-Sil (Department of Pharmacology, Colloge of Pharmacy, Chungang University) ;
  • Yun, Kang-Hee (Department of Pharmacology, Colloge of Pharmacy, Chungang University) ;
  • Ju, Song-Hyun (Department of Pharmacology, Colloge of Pharmacy, Chungang University) ;
  • Ryu, Jung-Su (Department of Pharmacology, Colloge of Pharmacy, Chungang University) ;
  • Sohn, Uy-Dong (Department of Pharmacology, Colloge of Pharmacy, Chungang University)
  • Published : 2003.10.01
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Abstract

The influence of melatonin on carrageenan-induced paw edema in Sprague-Dawley rats has been studied. The injection of 1% carrageenan (given at 0.1ml/paw) into the intraplantar induced an inflammatory response, and the maximal increase of paw volume, edema, was observed at 4hour. The levels of nitric oxide (NO), malondialdehyde (MDA) or prostaglandin E$_2$ (PGE$_2$) were increased after edema generation. Also, the expression of the inducible NO synthase (iNOS) were increased in the western blot. (omitted)

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