Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.69.3-70
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- 2003
Augmentation of constitutive nf-$textsc{k}$ b activation by bcl-2 in pc12 cells: implications for protection against oxidative stress
- Jang, Jung-Hee (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2003.10.01
Abstract
A substantial body of evidence indicates that reactive oxygen intermediates (ROIs) are implicated in pathogenesis of diverse human diseases, including cancer, diabetes and neurodegenerative disorders. Oxidative stress induced by ROIs often causes cell death via apoptosis that is regulated by a plenty of functional genes and their protein products. In the present work, we have investigated the role of bcl-2 in protecting against oxidative death induced by hydrogen peroxide in cultured rat pheochromocytoma (PC12) cells. (omitted)
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