Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.68.3-69
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- 2003
Inhibitory effect of DA-125 on cancer metastasis by downregulating MMPs and CAMs
- Park, Hyen-Joo (College of Pharmacy, Ewha Womans University) ;
- Hwang, Hye-Jin (Dong-A Pharmaceutical Co. LTD) ;
- Kim, Won-Bae (Dong-A Pharmaceutical Co. LTD) ;
- Kim, Soon-Hoe (Dong-A Pharmaceutical Co. LTD) ;
- Lee, Sang-Kook (Dong-A Pharmaceutical Co. LTD.)
- Published : 2003.10.01
Abstract
Matrix metalloproteinases (MMPs) play an important role in tumor invasion and metastasis by extracellular matrix degradation. To analyze the effect of DA-125, a anthracyclin derivative, on the invasion or metastasis of cancer cells the expression of matrix metalloproteases (MMPs) was investigated in human fibrosarcoma HTl080 cells by RT-PCR or gelatin zymographic methods. As result, DA-125 suppressed the expression of MMP-2 and 9 as well as tissue inhibitor of metalloproteinase-1 (TIMP-1) TIMP-2 and MT1-MMP with a time- and dose-dependent manner. Inaddition, DA-125 inhibited cancer cell migration and colony formation, and also exhibited the inhibitory activities of invasion and motility with a matrigel and type I collagen assay. (omitted)
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