Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.312.2-313
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- 2003
Dose-Independent Pharmacokinetics of a New Neuroprotective Agent for Ischemia-Reperfusion Damage, KR-31543, after Intravenous and Oral Administration to Rats: Hepatic and Intestinal First-Pass Effects
- Lee, Mi-Hye (College of Pharmacy, Seoul National University) ;
- Lee, Dae-Young (College of Pharmacy, Seoul National University) ;
- Bae, Soo-Kyung (College of Pharmacy, Seoul National University) ;
- Kim, Eun-Jung (College of Pharmacy, Seoul National University) ;
- Kim, Yoon-Gyoon (College of Pharmacy, Seoul National University) ;
- Kim, Sun-Ok (College of Pharmacy, Seoul National University) ;
- Lee, Dong-Ha (College of Pharmacy, Seoul National University) ;
- Lim, Hong (College of Pharmacy, Seoul National University) ;
- Yoo, Sung-Eun (College of Pharmacy, Seoul National University)
- Published : 2003.04.01
Abstract
The purpose of this study was to report dose-independent pharmacokinetics of KR-31543, a new neuroprotective agent for ischemia-reperfusion damage, after intravenous and oral administration and first-pass effects after intravenous. intraportal, intragastric, and intraduodenal administration in rats. After intravenous (10, 20 and 50 mg/kg) and oral (10, 20 and 50 mg/kg) administration, the pharmacokinetic parameters of KR-31543 were dose-independent. (omitted)
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