Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
- /
- Pages.310.2-311
- /
- 2003
Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous torasemide
- Kim, Yu-Chul (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
- Lee, Myung-Gull (Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Kangnung National University) ;
- Kim, So-Hee (Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Kangnung National University)
- Published : 2003.04.01
Abstract
The effects of differences in the rate and composition of intravenous fluid replacement for urine loss on the pharmacokinetics and pharmacodynamics of torasemide were evaluated using rabbits as the animal model. Each rabbit received 2-h constant intravenous infusion of 1 mg/kg ∼ 1 of torasemide with 0％ replacement (treatment I, n = 6), 50％ replacement (treatment II, n = 9), and 100％ replacement with lactated Ringer's solution (treatment III, n = 8) as well as with 100％ replacement with 5％ dextrose in water(D-5-W, treatment IV, n=6). (omitted)
Keywords