Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.310.1-310.1
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- 2003
Determination of a histone deacetylase inhibitor SD-2007 by LC/MS and application to a pharmacokinetic study in rats
- Shin, Beom-Soo (College of Pharmacy, Sungkyunkwan University) ;
- Yoon, Chi-Ho (College of Pharmacy, Sungkyunkwan University) ;
- Park, Min-Young (College of Pharmacy, Sungkyunkwan University) ;
- Jun, Yoon-Sik (College of Pharmacy, Sungkyunkwan University)
- Published : 2003.04.01
Abstract
SD-2007 ia an apicidin analogue, possessing a potent histone deacetylase inhibiting activity. A rapid and senstive LC/MS method was developed for the determination of SD-2007 and its major active metabolite. apicidin. in rat serum. SD-2007 and apicidin was extracted by liquid-liquid extraction using methyl t-butyl ether. SD-2007 and apicidin were monitored in a SIM mode at m/z of 679 and 622, respectively. (omitted)
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