Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of Glucose Supplementation on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats with Water Deprivation for 72 Hours

  • Kim, Yu-Chul (College of Pharmacy, Seoul National University) ;
  • Kim, Eun-Jung (Department of Diagnostic Pathology, College of Medicine, University of Ulsa) ;
  • Lee, In-Chul (Department of Pharmacology, College of Dentistry, Kangnung National University) ;
  • Kim, Sang-Geon (Department of Pharmacology, College of Dentistry, Kangnung National University) ;
  • Lee, Myung-Gull (Department of Pharmacology, College of Dentistry, Kangnung National University) ;
  • Kim, So-Hee (Department of Pharmacology, College of Dentistry, Kangnung National University)
  • Published : 2003.04.01
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Abstract

In rats with water deprivation for 72 h (rats with dehydration), hepatic cytochrome P450 2E1 (CYP2E1) was 3-fold induced with an increase in mRNA, and glucose supplementation instead of food during 72-h water deprivation inhibited the CYP2E1 induction. Chlorzoxazone (CZX) is metabolized to 6-hydroxychlorzoxazone (OH-CZX) mainly by CYP2E1 in rats. (omitted)

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