대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.306.2-307
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- 2003
Drug Interaction between Verapamil and Paclitaxel in Rats
- Park, Jun-Shik (College of Pharmacy, Chosun University) ;
- Park, Hyun-Jin (College of Pharmacy, Chosun University)
- 발행 : 2003.04.01
초록
The purpose of this study was to investigate the effect of verapamil (5, 10, 20 mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel (50 mg/kg) orally coadministered in rats. The plasma concentration of paclitaxel with verapamil increased dose-dependently, and increased significantly in both coadministration (p<0.05) and pretreatment group (p<0.01) compared to that of control. (omitted)
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