대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

A Simple and Rapid Determination of Theophylline in Human Serum by High-Performance liquid Chromatography and its Application to Pharmacokinetics of Theophylline in Volunteers

  • Park, Young-Jin (Toxicology Lab., Korea Institute of Science and Technology) ;
  • Kim, Hye-Jung (Toxicology Lab., Korea Institute of Science and Technolog) ;
  • Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
  • Kwon, Oh-Seung (Toxicology Lab., Korea Institute of Science and Technology)
  • 발행 : 2003.04.01
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초록

A simple and rapid method for the determination of theophylline (THP) in human serum was developed by a high performance liquid chromatography/UV detector and applied to pharmacokinetic study of THP in human volunteers. ${\beta}$-Hydroxyethyltheophylline as internal standard was added to 200 ${\mu}\ell$ of human serum and the mixture was centrifuged at 13000 rpm for 10 min. (omitted)

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