TGF-$\beta$1 Releasing Chitosan Microgranules for Bone Regeneration

  • Lee, Jue-Yeon (Department of Pharmacy, College of Pharmacy, Ewha Womans University) ;
  • Lee, Sun-Yoon (Department of Pharmacy, College of Pharmacy, Ewha Womans University) ;
  • Han, Sang-Mun (Department of Pharmacy, College of Pharmacy, Ewha Womans University) ;
  • Lee, Yong-Moo (Department of Pharmacy, College of Pharmacy, Ewha Womans University) ;
  • Rhyu, In-Chul (Department of Pharmacy, College of Pharmacy, Ewha Womans University) ;
  • Chung, Chong-Pyoung (Department of Pharmacy, College of Pharmacy, Ewha Womans University)
  • Published : 2003.04.01

Abstract

For the purpose of obtaining high bone forming efficacy, chitosan microgranules were developed as bone substitutes. Chitosan has been applied to conduct the extracellular matrix (ECM) formation in tissue regenerative therapy. Microgranules designed in this study confer drug releasingcapacity in bone defect over long period to enhance bone regeneration. (omitted)

Keywords