대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.298.2-298.2
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- 2003
Enhanced in vitro/in vivo Characteristics of Glucagon-like Peptide-1 by PEGylation
- Han, H.S. (Drug Targeting Laboratory, SungKyunKwan University) ;
- Youn, Y.S. (Drug Targeting Laboratory, SungKyunKwan University) ;
- Oh, S.H. (Drug Targeting Laboratory, SungKyunKwan University) ;
- Hong, S.T. (Drug Targeting Laboratory, SungKyunKwan University) ;
- Lee, J.E. (Drug Targeting Laboratory, SungKyunKwan University) ;
- Lee, S.O. (Drug Targeting Laboratory, SungKyunKwan University) ;
- Lee, K.C. (Drug Targeting Laboratory, SungKyunKwan University,)
- 발행 : 2003.04.01
초록
The insulinotropic hormone, glucagons-like peptide-1 (GLP-1), which has been proposed as a new potential therapeutics for type-II diabetes, but this is metabolized extremely rapidly by the ubiquitous enzyme, dipeptidyl peptidase IV (DPP IV), forming a metabolite, which acts as an antagonist at the GLP-1 receptor. (omitted)
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