대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Protective Effects of Acanthoic acid on Tertiary-Butyl Hydroperoxide or Carbon tetrachloride-Induced Liver Injury

  • Park, Eun-Jeon (Department of Pharmacy, Wonkwang University) ;
  • Nan, Ji-Xing (College of Pharmacy, Chungnam National University) ;
  • Zhao, Yu-Zhe (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Lee, Sung-Hee (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Kim, Young-Ho (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Nam, Jeong-Bum (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Lee, Jung-Joon (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Sohn, Dong-Hwan (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology)
  • 발행 : 2003.04.01
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초록

The aim of this study was to investigate the protective effect of acanthoic acid on liver injury induced by either tertiary-butyl hydroperoxide (tBH) or carbon tetrachloride in vitro and in vivo. Acanthoic acid, (-)-pimara-9(11),15-diene-19-oic acid, is a diterpene isolated from the root bark of Acanthopanax koreanum. In in vitro study, the cellular leakage of lactate dehydrogenase (LDH) with 1.5 mM tBH for 1 j, were significantly inhibited by treatment with acanthoic acid(25 and 5mg/mL). (omitted)

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