Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.296.2-296.2
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- 2003
Formulation and Biopharmaceutical Evaluation of Silymarin Using Self-MicroEmulsifying Drug Delivery Systems
- Kim, Tae-Seo (College of Pharmacy, Sungkyunkwan University) ;
- Park, Jae-Hyun (College of Pharmacy, Sungkyunkwan University) ;
- Chi, Sang-Cheol (College of Pharmacy, Sungkyunkwan University) ;
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Woo, Jong-Soo
(Pharmaceutical R＆D center, Hanmi Pharm. Co., Ltd.)
- Published : 2003.04.01
Abstract
Carduus marianus extract (formally called silymarin) have been used mainly as a medicament for hepatobiliary diseases. The major component of silymarin is silybin, which constitutes between 50 and 70％ of the drug and is the major active component. Many experiments show the efficacy of silybin parenterally administerated. But, its bioavalability is low after oral administration due to its low solubility in water. (omitted)
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