Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Receptor-mediated gene delivery to hepatocyte with galatosylated polyethylenimine

  • Kim, In-Sook (College of Pharmacy, Chonnam National University) ;
  • Oh, In-Joon (College of Pharmacy, Chonnam National University) ;
  • Kim, Sung-Ho (College of Pharmacy, Chosun University)
  • Published : 2003.04.01
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Abstract

In the gene therapy. viral gene delivery systems are limited in use because of several drawbacks like host immune reactions. Hence, non-viral gene delivery systems such as cationic polymers or synthetic gene carriers are being widely investigated to overcome the problems in the use of viral vectors. We synthesized a new conjugate of polyethyleniminet carrying galactose moieties as a targeting ligand for asialoglycoprotein (ASGP) receptors of hepatocytes. (omitted)

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