Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Transport of anti-allergic drugs across the passage cultured human nasal epithelial cell monolayer

  • Lin, Hongxia (College of Pharmacy, Pusan National University) ;
  • Yoo, Jin-Wook (College of Pharmacy, Pusan National University) ;
  • Lee, Chi-Ho (College of Pharmacy, Pusan National University) ;
  • Kim, Dae-Duk (College of Pharmacy, Pusan National University)
  • Published : 2003.04.01
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Abstract

The purpose of this study was to investigate the transport characteristics of passage cultured l1uman nasal epithelial cell monolayers grown on Transwell@ inserts using liquid-covered culture (LCC) method. The monolayer of passage 2 and 3 exhibited tight barrier (TEER>1,000 ohmxcm$^2$) in 2-3 days after seeding. In the morphological studies by actin staining and SEM/TEM, the existence of tight junction was clearly observed. (omitted)

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