대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.286.2-287
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- 2003
In vitro metabolism of a new protective agent, KR-31543 in human liver microsomes
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Ji, Hye-Young
(College of Pharmacy, Wonkwang University) ;
- Kim, Sook-Jin (AgroPharma Research Institute, DonbuHannong Chemical C) ;
- Lee, Hong-Il (AgroPharma Research Institute, DonbuHannong Chemical C) ;
- Lee, Seung-Seok (AgroPharma Research Institute, DonbuHannong Chemical C) ;
- Lee, Dong-Ha (AgroPharma Research Institute, DonbuHannong Chemical C) ;
- Lim, Hong (AgroPharma Research Institute, DonbuHannong Chemical C) ;
- Lee, Hye-Suk (AgroPharma Research Institute, DonbuHannong Chemical Co)
- 발행 : 2003.04.01
초록
The purpose of this paper was to identify the metabolic pathway of a new neuroprotective agent, KR-31543 for ischemia-reperfusion damage in human liver microsomes and characterize cytochrome P450 (CYP) enzymes involved in the in vitro metabolism of KR-31543 generates two metabolites in human liver microsomes : M1, N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine and M2, hydroxy-KR-31543. (omitted)
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