Chiral Separation of Non-Steroidal Inflammatory Drugs as Dual Diastereomeric Derivatives with (R)-and (S)-Phenylethylamines

  • Lee, Yoon-Suk (College of Pharmacy, Sungkyunkwan University) ;
  • Paik, Man-Jeong (College of Pharmacy, Sungkyunkwan University, Kyonggi Pharmaceutical Research Cente) ;
  • Kim, Kyoung-Rae (College of Pharmacy, Sungkyunkwan University)
  • Published : 2003.04.01

Abstract

The carboxylated acidic non-steroidal antiinflammatory drugs (NSAIDs) constitute the principal class of agents for controlling the pain and inflammation of the rheumatic diseases. It is mostly administered as a racemic mixture like most other drugs with asymmetric carbon atoms. However enantiomers of many racemic drug substances have been shown to posses different pharmacological toxicological properties. (omitted)

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