Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Determination of dextromethorphan and its metabolite dextrorphan in human urine by High-performance liquid chromatography

  • Son, Haeng-Ja (Dept of Forensic science, National Institute of Scientific Investigation) ;
  • Park, Mee-Jung (Dept of Forensic science, National Institute of Scientific Investigatio) ;
  • Choi, Sang-Kil (Dept of Forensic science, National Institute of Scientific Investigatio) ;
  • Lim, Mi-Ae (Dept of Forensic science, National Institute of Scientific Investigatio) ;
  • Chung, Hee-Sun (Dept of Forensic science, National Institute of Scientific Investigation)
  • Published : 2003.04.01
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Abstract

A simple and accurate reverse-phase high performance liquid chromatography (HPLC) coupled with photodiode array was developed for the determination of dextromethorphan(DM) and its metabolite dextrorphan(DX) in human urine. Chromatographic separation was accomplished on a cyano analytical column at 220 nm using a mobile phase containing 25 mM triethylammonium phosphate buffer(PH 3.0) in a 0-70％ ACN gradient and triazolam(TZ) was used as internal standard(I.S). (omitted)

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